Endothelin Knockout Mice and Cardiovascular Development
نویسندگان
چکیده
منابع مشابه
Endothelin-1 Overexpression Improves Renal Function in eNOS Knockout Mice.
BACKGROUND/AIMS To investigate the renal phenotype under conditions of an activated renal ET-1 system in the status of nitric oxide deficiency, we compared kidney function and morphology in wild-type, ET-1 transgenic (ET+/+), endothelial nitric oxide synthase knockout (eNOS-/-) and ET+/+eNOS-/- mice. METHODS We assessed blood pressure, parameters of renal morphology, plasma cystatin C, urinar...
متن کاملResponses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice.
The molecular mechanism responsible for salt sensitivity is poorly understood. Mice heterozygous for the null mutation of the endothelin-1 (ET-1) gene, Edn1, may be a potential tool for studying this mechanism, because they have elevated blood pressure and disturbances in central sympathetic nerve regulation. In the present study, we used this mouse model to examine the degree to which ET-1 con...
متن کاملAdrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice.
Polymorphism of the dopamine receptor type-2 (D(2)) gene is associated with essential hypertension. To assess whether D(2) receptors participate in regulation of blood pressure (BP), we studied mice in which the D(2) receptor was disrupted. In anesthetized mice, systolic and diastolic BPs (in millimeters of mercury) were higher in D(2) homozygous and heterozygous mutant mice than in D(2)+/+ lit...
متن کاملNormal sexual development and fertility in testatin knockout mice.
The testatin gene was previously isolated in a screen focused on finding novel signaling molecules involved in sex determination and differentiation. testatin is specifically upregulated in pre-Sertoli cells in early fetal development, immediately after the onset of Sry expression, and was therefore considered a strong candidate for involvement in early testis development. testatin expression i...
متن کاملEndothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein E knockout mice.
OBJECTIVE Endothelin (ET)-1 plays a role in vascular reactive oxygen species production and inflammation. ET-1 has been implicated in human atherosclerosis and abdominal aortic aneurysm (AAA) development. ET-1 overexpression exacerbates high-fat diet-induced atherosclerosis in apolipoprotein E(-/-) (Apoe(-/-)) mice. ET-1-induced reactive oxygen species and inflammation may contribute to atheros...
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ژورنال
عنوان ژورنال: Proceedings of The Japanese Society of Animal Models for Human Diseases
سال: 1999
ISSN: 0918-8991,1884-4197
DOI: 10.1538/expanim1992.15.3